SCHEMBL7837749

SCHEMBL7837749

Nc1cccc2c(S(=O)(=O)N3CCCCC3)cccc12

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.77
KMT2A Q03164 4/20 0.67
MEN1 O00255 3/20 0.67
ATM Q13315 1/20 0.64
TSHR P16473 6/20 0.61
CYP3A4 P08684 3/20 0.61
CYP2C9 P11712 2/20 0.61
CYP2C19 P33261 2/20 0.61
ALDH1A1 P00352 4/20 0.59
TTR P02766 1/20 0.53
TP53 P04637 2/20 0.52
CYP1A2 P05177 2/20 0.52
CYP2D6 P10635 2/20 0.52
NFKB1 P19838 2/20 0.52
MAPK1 P28482 2/20 0.52
MYLK Q15746 2/20 0.52
ROCK1 Q13464 3/20 0.52
ROCK2 O75116 2/20 0.52
PRKX P51817 1/20 0.52
PRKCE Q02156 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13788913 0.84 KMT2A (0.63) SMN1; SMN2KMT2AMEN1ATMALDH1A1
SCHEMBL11200997 0.83 TSHR (0.65) SMN1; SMN2KMT2AMEN1ATMTSHR
SCHEMBL8140330 0.83 TSHR (0.75) SMN1; SMN2KMT2AMEN1TSHRCYP3A4
SCHEMBL1439966 0.83 TSHR (0.75) SMN1; SMN2KMT2AMEN1TSHRCYP3A4
SCHEMBL10719519 0.82 SMN1; SMN2 (0.80) SMN1; SMN2KMT2AMEN1ATMTSHR
SCHEMBL25532 0.81 POLB (0.58) SMN1; SMN2KMT2AMEN1ATMTSHR
SCHEMBL10876385 0.81 SMN1; SMN2 (0.62) SMN1; SMN2KMT2AMEN1ATMTSHR
SCHEMBL5342056 0.81 TSHR (0.71) SMN1; SMN2KMT2AMEN1ATMTSHR
SCHEMBL12086998 0.81 TSHR (0.61) SMN1; SMN2KMT2AMEN1ATMTSHR
SCHEMBL29452018 0.81 TSHR (0.61) SMN1; SMN2KMT2AMEN1ATMTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144381-A2 SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES MERCK PATENT GmbH (DE) 2001-10-17 EP disclosed
WO-2000032577-A2 SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES MERCK PATENT GMBH (DE) 2000-06-08 WO disclosed