Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | MITF | O75030 | 4/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 11/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451929 | 0.92 | RAB9A (0.58) | RAB9APAX8NPC1MITFPRMT5 | |
| SCHEMBL29452088 | 0.84 | RAB9A (0.59) | RAB9APAX8NPC1MITFPRMT5 | |
| SCHEMBL29451668 | 0.83 | RAB9A (0.63) | RAB9APAX8NPC1MITFPRMT5 | |
| SCHEMBL29452016 | 0.76 | PRMT5 (0.57) | RAB9APAX8NPC1MITFPRMT5 | |
| SCHEMBL29451608 | 0.76 | RAB9A (0.76) | RAB9APAX8NPC1MITFPRMT5 | |
| SCHEMBL29451409 | 0.74 | PRMT5 (0.68) | RAB9APAX8NPC1MITFPRMT5 | |
| SCHEMBL29451563 | 0.73 | RAB9A (0.60) | RAB9APAX8NPC1MITFPRMT5 | |
| SCHEMBL29451868 | 0.73 | RAB9A (0.60) | RAB9APAX8NPC1MITFPRMT5 | |
| SCHEMBL29451735 | 0.72 | PRMT5 (0.80) | RAB9APAX8NPC1MITFPRMT5 | |
| SCHEMBL29452248 | 0.68 | ALDH1A1 (0.64) | RAB9APAX8NPC1MITFPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |