Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 13/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198777 | 1.00 | GPR52 (1.00) | GPR52TP53HPGDKDM4ELMNA | |
| SCHEMBL3218938 | 0.94 | GPR52 (0.88) | GPR52HPGDALOX15 | |
| SCHEMBL3204292 | 0.94 | GPR52 (0.88) | GPR52TP53HPGDKDM4ELMNA | |
| SCHEMBL3210142 | 0.93 | GPR52 (0.87) | GPR52TP53HPGDLMNAMAPT | |
| SCHEMBL3204403 | 0.93 | GPR52 (0.86) | GPR52TP53LMNAMAPTSNCA | |
| SCHEMBL3213566 | 0.92 | GPR52 (0.85) | GPR52TP53SNCA | |
| SCHEMBL3197888 | 0.90 | GPR52 (0.81) | GPR52MRGPRX4 | |
| SCHEMBL3210761 | 0.90 | GPR52 (0.81) | GPR52TP53HPGDKDM4ELMNA | |
| SCHEMBL3220886 | 0.90 | GPR52 (0.81) | GPR52LMNASNCA | |
| SCHEMBL13489581 | 0.90 | GPR52 (0.81) | GPR52TP53HPGDKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515681-B | GPR52 modulator compounds | 奈克斯拉制药英国有限公司 | 2024-09-03 | — | — | CN | disclosed |
| EP-4401833-A1 | GPR52 MODULATOR COMPOUNDS | Nxera Pharma UK Limited (GB) | 2024-07-24 | — | — | EP | disclosed |
| CN-117999258-A | GPR52 modulator compounds | 赫普泰雅治疗有限公司 | 2024-05-07 | — | — | CN | disclosed |
| EP-4204408-A1 | GPR52 MODULATOR COMPOUNDS | Heptares Therapeutics Limited (GB) | 2023-07-05 | — | — | EP | disclosed |
| WO-2023041909-A1 | GPR52 MODULATOR COMPOUNDS | HEPTARES THERAPEUTICS LIMITED (GB) | 2023-03-23 | — | — | WO | disclosed |
| EP-4117784-A1 | GPR52 MODULATOR COMPOUNDS | Heptares Therapeutics Limited (GB) | 2023-01-18 | — | — | EP | disclosed |
| EP-4055016-A1 | GPR52 MODULATOR COMPOUNDS | Heptares Therapeutics Limited (GB) | 2022-09-14 | — | — | EP | disclosed |
| WO-2022043714-A1 | GPR52 MODULATOR COMPOUNDS | HEPTARES THERAPEUTICS LIMITED (GB) | 2022-03-03 | — | — | WO | disclosed |