Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 10/20 | 0.40 |
| ▸ | PLK1 | P53350 | 14/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20108162 | 0.79 | KMT2A (0.48) | NEK2PLK1PLK3KDM4E | |
| SCHEMBL3156518 | 0.78 | PLK1 (0.42) | NEK2PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL3569266 | 0.77 | PLK1 (0.42) | NEK2PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL29453063 | 0.76 | PLK1 (0.51) | NEK2PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL29536039 | 0.76 | PLK1 (0.51) | NEK2PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL3963311 | 0.76 | PLK1 (0.51) | NEK2PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL4632899 | 0.75 | PLK1 (0.35) | NEK2PLK1PLK3AURKACDK2 | |
| SCHEMBL30427708 | 0.75 | PLK1 (0.44) | NEK2PLK1PLK3AURKACDK2 | |
| SCHEMBL14047869 | 0.72 | PLK1 (0.34) | NEK2PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL25267168 | 0.69 | PLK1 (0.49) | NEK2PLK1PLK3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |