Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.46 |
| ▸ | FEN1 | P39748 | 4/20 | 0.46 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27211398 | 1.00 | HPGDS (0.46) | HPGDSALOX5APFEN1TRPV3JAK2 | |
| SCHEMBL25343562 | 1.00 | HPGDS (0.46) | HPGDSALOX5APFEN1TRPV3JAK2 | |
| SCHEMBL17898219 | 0.79 | TRPV3 (0.50) | HPGDSALOX5APFEN1TRPV3JAK2 | |
| SCHEMBL19203194 | 0.78 | HPGDS (0.46) | HPGDSALOX5APFEN1TRPV3JAK2 | |
| SCHEMBL30473720 | 0.77 | HPGDS (0.48) | HPGDSALOX5APFEN1TRPV3JAK2 | |
| SCHEMBL25346096 | 0.77 | HPGDS (0.48) | HPGDSALOX5APFEN1TRPV3JAK2 | |
| SCHEMBL27211270 | 0.77 | HPGDS (0.48) | HPGDSALOX5APFEN1TRPV3JAK2 | |
| SCHEMBL9962296 | 0.77 | TRPV3 (0.53) | HPGDSALOX5APFEN1TRPV3JAK2 | |
| SCHEMBL23705673 | 0.77 | TRPV3 (0.46) | HPGDSALOX5APFEN1TRPV3JAK2 | |
| SCHEMBL14991675 | 0.77 | TRPV3 (0.46) | HPGDSALOX5APFEN1TRPV3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116390917-A | MRGX2 antagonists | 葛兰素史密斯克莱知识产权发展有限公司 | 2023-07-04 | — | — | CN | disclosed |
| WO-2022073904-A1 | MRGX2 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-04-14 | — | — | WO | disclosed |