SCHEMBL29458124

SCHEMBL29458124

CN(C)CCOc1cc([N+](=O)[O-])ccc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.58
CHRNA4 P43681 1/20 0.58
MAPT P10636 5/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
HPGD P15428 3/20 0.49
RAB9A P51151 2/20 0.49
LMNA P02545 2/20 0.49
ALDH1A1 P00352 2/20 0.49
NPC1 O15118 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
KMT2A Q03164 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
CYP19A1 P11511 6/20 0.48
KDM4E B2RXH2 1/20 0.48
GAA P10253 1/20 0.48
HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7396303 1.00 CHRNB2 (0.58) CHRNB2CHRNA4MAPTSMN1; SMN2HPGD
SCHEMBL9099265 0.92 CHRNB2 (0.51) CHRNB2CHRNA4MAPTSMN1; SMN2HPGD
SCHEMBL29769084 0.89 MAPT (0.62) CHRNB2CHRNA4MAPTSMN1; SMN2HPGD
SCHEMBL3442514 0.89 MAPT (0.62) CHRNB2CHRNA4MAPTSMN1; SMN2HPGD
SCHEMBL4548252 0.84 CHRNB2 (0.59) CHRNB2CHRNA4MAPTALDH1A1CYP3A4
SCHEMBL5509909 0.84 CHRNB2 (0.59) CHRNB2CHRNA4ALDH1A1CYP3A4CYP19A1
SCHEMBL1663340 0.84 CYP19A1 (0.59) MAPTSMN1; SMN2HPGDRAB9ALMNA
SCHEMBL5275797 0.83 CHRNB2 (0.58) CHRNB2CHRNA4MAPTSMN1; SMN2HPGD
SCHEMBL1219905 0.83 CHRNB2 (0.58) CHRNB2CHRNA4MAPTSMN1; SMN2HPGD
SCHEMBL7399032 0.83 CHRNB2 (0.58) CHRNB2CHRNA4MAPTSMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116635390-A Potent and selective compounds as serotonin 1B receptor modulators 莱科斯生物技术公司 2023-08-22 CN disclosed
EP-4225753-A1 POTENT AND SELCTIVE COMPOUNDS AS SEROTONIN 1B RECEPTOR MODULATORS Leukos Biotech, S.L. (ES) 2023-08-16 EP disclosed
WO-2022074103-A1 POTENT AND SELCTIVE COMPOUNDS AS SEROTONIN 1B RECEPTOR MODULATORS LEUKOS BIOTECH, S.L. (ES) 2022-04-14 WO disclosed