Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 8/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CFD | P00746 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3775553 | 0.85 | PTGER4 (0.60) | PTGER4CNR1ELANECYP2D6PARP1 | |
| SCHEMBL31647277 | 0.85 | PTGER4 (0.60) | PTGER4CNR1ELANECYP2D6PARP1 | |
| SCHEMBL24273625 | 0.84 | PTGER4 (0.62) | PTGER4CNR1ELANECYP2D6PARP1 | |
| SCHEMBL13671617 | 0.79 | CNR1 (0.50) | PTGER4CNR1ELANECYP2D6PARP1 | |
| SCHEMBL6114223 | 0.78 | PTGER4 (0.57) | PTGER4CNR1CYP2D6 | |
| SCHEMBL8591344 | 0.78 | PTGER4 (0.52) | PTGER4CNR1ELANECYP2D6CFD | |
| SCHEMBL31647362 | 0.78 | PTGER4 (0.58) | PTGER4CNR1ELANECYP2D6 | |
| SCHEMBL14584183 | 0.78 | RORC (0.58) | ELANECYP2D6PARP1CFDCYP1A2 | |
| SCHEMBL3771874 | 0.77 | CNR1 (0.51) | PTGER4CNR1ELANECYP2D6PARP1 | |
| SCHEMBL6852969 | 0.77 | CNR1 (0.48) | PTGER4CNR1ELANECYP2D6PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4213839-A2 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-07-26 | — | — | EP | disclosed |
| CN-116438162-A | Modulators of MAS-related G protein receptor X4 and related products and methods | 伊赛恩特制药公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022061008-A2 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-03-24 | — | — | WO | disclosed |