Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 1/20 | 0.60 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.60 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22534019 | 1.00 | SCN4A (0.60) | SCN4ASCN9ASCN3ADRD2DRD3 | |
| SCHEMBL22534018 | 1.00 | SCN4A (0.60) | SCN4ASCN9ASCN3ADRD2DRD3 | |
| SCHEMBL22533895 | 0.83 | SCN4A (0.65) | SCN4ASCN9ASCN3ADRD2DRD3 | |
| SCHEMBL6885051 | 0.81 | KDM4E (0.67) | SCN4ASCN9ASCN3ADRD2DRD3 | |
| SCHEMBL6883734 | 0.79 | KDM4E (0.68) | SCN4ASCN9ASCN3ADRD2DRD3 | |
| SCHEMBL6885191 | 0.79 | KDM4E (0.68) | SCN4ASCN9ASCN3ADRD2DRD3 | |
| SCHEMBL75509 | 0.78 | KDM4E (0.67) | SCN4ASCN9ASCN3ADRD2DRD3 | |
| SCHEMBL18767312 | 0.77 | MAOB (0.67) | SCN4ASCN9ASCN3ADRD2DRD3 | |
| SCHEMBL22534020 | 0.75 | MAOB (0.60) | SCN4ASCN9ASCN3ADRD2DRD3 | |
| SCHEMBL18767964 | 0.74 | SLC6A2 (0.59) | SCN4ASCN9ASCN3ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3953350-A1 | D3 RECEPTOR AGONIST COMPOUNDS; METHODS OF PREPARATION; INTERMEDIATES THEREOF; AND METHODS OF USE THEREOF | The United States of America, as Represented by The Department of Health and Human Services (US) | 2022-02-16 | — | — | EP | disclosed |