Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11920690 | 1.00 | HSD11B1 (0.38) | HSD11B1PRKCAPTPN2HTR7ADRA1A | |
| SCHEMBL7157630 | 0.87 | HSD11B1 (0.43) | HSD11B1PRKCAPTPN2HTR7ADRA1A | |
| SCHEMBL30419444 | 0.87 | HSD11B1 (0.43) | HSD11B1PRKCAPTPN2HTR7ADRA1A | |
| SCHEMBL21246371 | 0.83 | MAP3K12 (0.41) | HSD11B1PRKCAPTPN2HTR7ADRA1A | |
| SCHEMBL22540300 | 0.81 | MAP3K12 (0.40) | HSD11B1PRKCAPTPN2HTR7ADRA1A | |
| SCHEMBL4075017 | 0.81 | ALDH1A1 (0.31) | — | |
| SCHEMBL31221400 | 0.80 | GRIN1 (0.44) | HSD11B1PRKCAPTPN2HTR7ADRA1A | |
| SCHEMBL626328 | 0.80 | GRIN1 (0.44) | HSD11B1PRKCAPTPN2HTR7ADRA1A | |
| SCHEMBL15862755 | 0.80 | GRIN1 (0.47) | HSD11B1PRKCAPTPN2HTR7ADRA1A | |
| SCHEMBL20887344 | 0.80 | HSD11B1 (0.38) | HSD11B1PRKCAPTPN2HTR7ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081666-A1 | COMPOUNDS AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-108602777-B | 3- ((hetero-) aryl) -alkyl-8-amino-2-oxo-1, 3-aza-spiro- [4.5] -decane derivative | 格吕伦塔尔有限公司 | 2022-05-03 | — | — | CN | disclosed |
| CN-114149413-A | 3- ((hetero) aryl) -8-amino-2-oxo-1, 3-aza-spiro- [4.5] -decane derivatives | 格吕伦塔尔有限公司 | 2022-03-08 | — | — | CN | disclosed |