Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31011141 | 1.00 | CES2 (0.56) | CES2KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL642821 | 1.00 | CES2 (0.56) | CES2KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL642822 | 1.00 | CES2 (0.56) | CES2KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL16043416 | 0.81 | ACHE (0.50) | — | |
| SCHEMBL16043421 | 0.81 | ACHE (0.50) | — | |
| SCHEMBL17134217 | 0.80 | CES2 (0.64) | CES2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL15229092 | 0.80 | CES2 (0.50) | CES2KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL627579 | 0.80 | CES2 (0.50) | CES2KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL28216626 | 0.80 | KMT2A (0.59) | CES2KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL745694 | 0.78 | CES2 (0.56) | CES2KMT2AHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269340-A | KCNT1 inhibitors and methods of use | 普拉克西斯精密药物股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| EP-3962481-A1 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |