SCHEMBL294637

SCHEMBL294637

COC(=O)CCC1OCC2(CO1)COC(CCC(=O)OC)OC2

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.43
KMT2A Q03164 3/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 3/20 0.33
CA12 O43570 2/20 0.33
CA14 Q9ULX7 2/20 0.33
GLA P06280 1/20 0.33
KDM4E B2RXH2 1/20 0.33
EPHX2 P34913 4/20 0.33
CA2 P00918 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HSD17B10 Q99714 2/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
HTT P42858 1/20 0.32
SIRT2 Q8IXJ6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30456378 0.87 TSHR (0.41) TSHRKMT2AMEN1LMNACA12
SCHEMBL30510726 0.84 TSHR (0.50) TSHRKMT2AMEN1LMNACA12
SCHEMBL22104292 0.81 TSHR (0.36) TSHRKMT2AMEN1HSD17B10ALDH1A1
SCHEMBL294976 0.76 LMNA (0.33) TSHRKMT2AMEN1LMNAHSD17B10
SCHEMBL9225256 0.75 TSHR (0.41) TSHREPHX2SMN1; SMN2ALDH1A1MAPT
SCHEMBL4412118 0.74 POLB (0.38) KMT2AMEN1KDM4EALDH1A1MAPT
SCHEMBL4081536 0.74 TSHR (0.48) TSHRKMT2AMEN1LMNACA12
SCHEMBL21779452 0.73 PSMB8 (0.31)
SCHEMBL17407789 0.72
SCHEMBL9665578 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014097270-A1 FIBER REINFORCED POLYOXYMETHYLENE COMPOSITION WITH IMPROVED THERMAL PROPERTIES TICONA GMBH (DE) 2014-06-26 WO disclosed
US-8440300-B2 Coated polyoxymethylenes BASF SE (DE) 2013-05-14 US disclosed
EP-2235092-B1 COATED POLYOXYMETHYLENES BASF SE (DE) 2012-03-14 EP disclosed
US-20100291389-A1 COATED POLYOXYMETHYLENES BASF SE PATENTS, TRADEMARKS AND LICENSES (DE) 2010-11-18 US disclosed
EP-2235092-A1 COATED POLYOXYMETHYLENES BASF SE (DE) 2010-10-06 EP disclosed
WO-2009092698-A1 COATED POLYOXYMETHYLENES BASF SE (DE) 2009-07-30 WO disclosed
US-20090143506-A1 Aldehyde inhibitor composition and polyacetal resin composition POLYPLASTICS CO., LTD. (JP) 2009-06-04 US disclosed
US-20070073007-A1 Polyacetal resin composition and molded article thereof POLYPLASTICS CO., LTD. (JP) 2007-03-29 US disclosed
EP-1522554-B1 Polyacetal resin composition and shaped article thereof POLYPLASTICS CO (JP) 2006-11-22 EP disclosed
EP-1522554-A1 Polyacetal resin composition and shaped article thereof Polyplastics Co., Ltd. (JP) 2005-04-13 EP disclosed
US-3968084-A Curable composition of epoxy resin and cured product thereof BRIDGESTONE TIRE COMPANY LIMITED (JA) 1976-07-06 US disclosed
US-3941732-A 3,9-(2-HYDRAZIDOETHYL)-2,4,8,10-TETRAOXASPIRO-(5,5)-UNDECANE STIFFENER BRIDGESTONE TIRE COMPANY LIMITED (JA) 1976-03-02 US disclosed
US-3940369-A Method for preparing polyurethanes using 3,9-bis(2-hydrazidoethyl)-2-4,8,10-tetraoxaspiro-[5,5]-undecane as chain extender BRIDGESTONE TIRE COMPANY LIMITED (JA) 1976-02-24 US disclosed