Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510726 | 0.88 | TSHR (0.50) | TSHRLMNAKDM4EGLAALDH1A1 | |
| SCHEMBL3588952 | 0.82 | TSHR (0.45) | TSHRLMNAALDH1A1SMN1; SMN2MGAM | |
| SCHEMBL7373034 | 0.78 | TSHR (0.50) | TSHRLMNAGLAALDH1A1KMT2A | |
| SCHEMBL414516 | 0.78 | TSHR (0.50) | TSHRLMNAGLAALDH1A1KMT2A | |
| SCHEMBL10481290 | 0.77 | TSHR (0.81) | TSHRLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL25187 | 0.77 | TSHR (0.81) | TSHRLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL4080821 | 0.76 | ACE (0.43) | LMNAKDM4EGLAALDH1A1KMT2A | |
| SCHEMBL6081635 | 0.75 | GAA (0.47) | TSHRLMNAALDH1A1HSD17B10EPHX2 | |
| SCHEMBL5104542 | 0.74 | TSHR (0.50) | TSHRLMNAGLAALDH1A1KMT2A | |
| SCHEMBL294637 | 0.74 | TSHR (0.43) | TSHRLMNAKDM4EGLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560257-B2 | Diagnostic methods for age related macular degeneration | THE CLEVELAND CLINIC FOUNDATION (US) | 2009-07-14 | — | — | US | disclosed |
| WO-2008089485-A2 | CARBOXYETHYLPYRROLE COMPOUNDS AND METHODS OF THEIR PRODUCTION | THE CLEVELAND CLINIC FOUNDATION (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008089487-A2 | CARBOXYETHYLPYRROLE COMPOUNDS AND METHODS OF THEIR PRODUCTION | THE CLEVELAND CLINIC FOUNDATION (US) | 2008-07-24 | — | — | WO | disclosed |
| US-20080160505-A1 | DIAGNOSTIC METHODS FOR AGE RELATED MACULAR DEGENERATION | THE CLEVELAND CLINIC FOUNDATION | 2008-07-03 | — | — | US | disclosed |
| US-7341839-B2 | Diagnostic methods for age related macular degeneration | THE CLEVELAND CLINIC FOUNDATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-20070072241-A1 | diagnosing age-related macular degeneration comprising determining the level of anti-2-( omega -carboxyethyl) pyrrole (CEP) antibodies in a bodily fluid obtained from the test subject | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-03-29 | — | — | US | disclosed |
| US-7172874-B2 | Diagnostic methods for age related macular degeneration | THE CLEVELAND CLINIC FOUNDATION (US) | 2007-02-06 | — | — | US | disclosed |
| US-20040265924-A1 | Diagnostic methods for age related macular degeneration | THE CLEVELAND CLINIC FOUNDATION | 2004-12-30 | — | — | US | disclosed |