Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
| ▸ | BDKRB1 | P46663 | 15/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13214217 | 0.92 | DGAT2 (0.40) | DGAT2BDKRB1DDR1GPBAR1 | |
| SCHEMBL13213716 | 0.84 | DGAT2 (0.46) | DGAT2BDKRB1DDR1GPBAR1 | |
| SCHEMBL13213790 | 0.84 | BDKRB1 (0.47) | BDKRB1 | |
| SCHEMBL2951273 | 0.80 | BDKRB1 (0.47) | BDKRB1 | |
| SCHEMBL2948506 | 0.79 | BDKRB1 (0.58) | BDKRB1 | |
| SCHEMBL2946615 | 0.78 | BDKRB1 (0.57) | BDKRB1 | |
| SCHEMBL2942750 | 0.78 | FFAR1 (0.34) | BDKRB1GPBAR1 | |
| SCHEMBL13214185 | 0.78 | BDKRB1 (0.46) | DGAT2BDKRB1DDR1GPBAR1 | |
| SCHEMBL13213847 | 0.77 | BDKRB1 (0.44) | BDKRB1 | |
| SCHEMBL13214030 | 0.75 | BDKRB1 (0.69) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396301-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091876-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2010-08-19 | — | — | WO | disclosed |