Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.54 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.54 |
| ▸ | NMUR1 | Q9HB89 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30973963 | 0.93 | OPRM1 (0.64) | OPRM1OPRK1EPHA2NMUR2NMUR1 | |
| SCHEMBL29464015 | 0.93 | MAPK8 (0.59) | OPRM1OPRK1MAPK8MAPK9MAPK10 | |
| SCHEMBL30799488 | 0.91 | OPRM1 (0.57) | OPRM1OPRK1EPHA2NMUR2NMUR1 | |
| SCHEMBL30544090 | 0.91 | OPRM1 (0.57) | OPRM1OPRK1MAPK8MAPK9MAPK10 | |
| SCHEMBL30498507 | 0.91 | EPHA2 (0.60) | OPRM1OPRK1MAPK8MAPK9MAPK10 | |
| SCHEMBL30509906 | 0.91 | OPRM1 (0.52) | OPRM1OPRK1MAPK8MAPK9MAPK10 | |
| SCHEMBL29520254 | 0.90 | KISS1R (0.62) | OPRM1OPRK1 | |
| SCHEMBL30943512 | 0.90 | NTSR2 (0.56) | OPRM1NMUR2NMUR1 | |
| SCHEMBL30458665 | 0.90 | OPRM1 (0.58) | OPRM1OPRK1NMUR2NMUR1 | |
| SCHEMBL29868580 | 0.90 | OPRM1 (0.59) | OPRM1OPRK1MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541402-B1 | C3A RECEPTOR AGONISTS FOR USE AGAINST ISCHEMIC BRAIN INJURY | PEKNA MARCELA (SE) | 2022-07-20 | — | — | EP | claimed |
| US-11266715-B2 | C3A receptor agonists for use against ischemic brain injury, stroke, traumatic brain injury, spinal cord injury and neurodegenerative disorders | PEKNA MARCELA (SE) | 2022-03-08 | — | — | US | claimed |
| EP-3541402-B1 | C3A RECEPTOR AGONISTS FOR USE AGAINST ISCHEMIC BRAIN INJURY | PEKNA MARCELA (SE) | 2022-07-20 | — | — | EP | disclosed |
| US-11266715-B2 | C3A receptor agonists for use against ischemic brain injury, stroke, traumatic brain injury, spinal cord injury and neurodegenerative disorders | PEKNA MARCELA (SE) | 2022-03-08 | — | — | US | disclosed |