Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 3/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951361 | 1.00 | ABL1 (0.34) | ABL1SMOKIF18ARORCAURKA | |
| SCHEMBL19927752 | 0.92 | PTPN11 (0.36) | KIF18ARORCALDH1A1PTPN11MEN1 | |
| SCHEMBL19925055 | 0.90 | ABL1 (0.33) | ABL1SMOKIF18AALDH1A1CTSA | |
| SCHEMBL19925143 | 0.90 | SMO (0.34) | SMOKIF18ARORCPTPN11MEN1 | |
| SCHEMBL19925185 | 0.89 | RORC (0.35) | ABL1KIF18ARORC | |
| SCHEMBL29464968 | 0.89 | RORC (0.35) | ABL1KIF18ARORC | |
| SCHEMBL23748045 | 0.88 | ALDH1A1 (0.38) | ABL1SMOALDH1A1KMT2ACTSA | |
| SCHEMBL19951393 | 0.87 | RORC (0.37) | ABL1KIF18ARORCAURKAAURKB | |
| SCHEMBL19927722 | 0.86 | RORC (0.37) | KIF18ARORCAURKAAURKBPTPN11 | |
| SCHEMBL19925624 | 0.86 | MEN1 (0.38) | KIF18ARORCPTPN11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |