Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 4/20 | 0.31 |
| ▸ | AURKA | O14965 | 4/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | RORB | Q92753 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925011 | 1.00 | DGAT1 (0.33) | DGAT1KCNH2CHRM4KIF18AAURKA | |
| SCHEMBL19925112 | 1.00 | DGAT1 (0.33) | DGAT1KCNH2CHRM4KIF18AAURKA | |
| SCHEMBL19951305 | 0.91 | DGAT1 (0.34) | DGAT1KCNH2CHRM4KIF18ARORC | |
| SCHEMBL22323138 | 0.91 | DGAT1 (0.35) | DGAT1KCNH2CHRM4KIF18APTPN11 | |
| SCHEMBL19951306 | 0.91 | DGAT1 (0.34) | DGAT1KCNH2CHRM4KIF18ARORC | |
| SCHEMBL29464518 | 0.91 | DGAT1 (0.34) | DGAT1KCNH2CHRM4KIF18ARORC | |
| SCHEMBL19925421 | 0.89 | SCN9A (0.33) | KIF18ARORCRORBS1PR1SCN9A | |
| SCHEMBL19951401 | 0.89 | SCN9A (0.33) | KIF18ARORCRORBS1PR1SCN9A | |
| SCHEMBL19925045 | 0.89 | RORC (0.33) | DGAT1KCNH2CHRM4KIF18ARORC | |
| SCHEMBL19925639 | 0.89 | DGAT1 (0.33) | DGAT1KCNH2CHRM4KIF18APTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |