Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925549 | 1.00 | HSD17B10 (0.50) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A | |
| SCHEMBL21906037 | 0.79 | HSD17B10 (0.50) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A | |
| SCHEMBL30665391 | 0.79 | HSD17B10 (0.50) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A | |
| SCHEMBL21906009 | 0.79 | HSD17B10 (0.50) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A | |
| SCHEMBL1828420 | 0.79 | HSD17B10 (0.50) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A | |
| SCHEMBL30841348 | 0.79 | HSD17B10 (0.50) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A | |
| SCHEMBL21906129 | 0.79 | HSD17B10 (0.50) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A | |
| SCHEMBL30990696 | 0.78 | ABL1 (0.49) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A | |
| SCHEMBL400161 | 0.76 | POLB (0.70) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A | |
| SCHEMBL15970465 | 0.76 | MAOA (0.53) | HSD17B10ABL1RIN1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024217557-A1 | SUBSTITUTED TETRAHYDROFURANS AS NAV1.8 INHIBITORS | 武汉人福创新药物研发中心有限公司 | 2024-10-24 | — | — | WO | disclosed |
| CN-118812519-A | Substituted tetrahydrofurans as Nav1.8 inhibitors | 武汉人福创新药物研发中心有限公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-117586180-A | Compounds useful as inhibitors of voltage-gated sodium channels | 广州费米子科技有限责任公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |