Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.52 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27289520 | 0.98 | POLB (0.68) | POLBMAPTHSD17B10NPC1RAB9A | |
| SCHEMBL11158130 | 0.85 | POLB (0.58) | POLBMAPTHSD17B10NPC1RAB9A | |
| SCHEMBL315141 | 0.85 | MAPT (0.59) | POLBMAPTHSD17B10NPC1RAB9A | |
| SCHEMBL19403521 | 0.85 | RAB9A (0.67) | POLBMAPTHSD17B10NPC1RAB9A | |
| SCHEMBL5658909 | 0.85 | MAPT (0.64) | POLBMAPTHSD17B10NPC1RAB9A | |
| SCHEMBL3182706 | 0.83 | ALDH1A1 (0.62) | POLBMAPTHSD17B10NPC1RAB9A | |
| SCHEMBL315313 | 0.83 | POLB (1.00) | POLBMAPTHSD17B10NPC1RAB9A | |
| SCHEMBL28006323 | 0.81 | MAPT (0.59) | POLBMAPTNPC1RAB9AKMT2A | |
| SCHEMBL7004086 | 0.81 | POLB (0.50) | POLBMAPTHSD17B10NPC1RAB9A | |
| SCHEMBL537743 | 0.80 | EHMT2 (0.59) | POLBMAPTHSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119350233-A | Preparation method of aryl sulfonic acid compound | 上海麦克林生化科技股份有限公司 | 2025-01-24 | — | — | CN | claimed |
| US-8669253-B2 | Methods for treating glaucoma and macular degeneration | DUKE UNIVERSITY (US) | 2014-03-11 | — | — | US | claimed |
| US-20110009463-A1 | GERANYLGERANYL TRANSFERASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | claimed |
| WO-2009051772-A1 | GERANYLGERANYL TRANSFERASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME | DUKE UNIVERSITY (US) | 2009-04-23 | — | — | WO | claimed |
| US-20080119524-A1 | PRENYLATION INHIBITORS CONTAINING DIMETHYLCYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | PHARMACEUTICAL PRODUCT DEVELOPMENT, INC. | 2008-05-22 | — | — | US | claimed |
| US-20070249010-A1 | Methods for treating glaucoma and macular degeneration | DUKE UNIVERSITY (US) | 2007-10-25 | — | — | US | claimed |
| US-20070149549-A1 | 3-(Pyrid-3-yl)-5-(thiophen-2-yl)-pyrazoles; prenyl-protein transferase inhibitors | PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC | 2007-06-28 | — | — | US | claimed |
| EP-1534279-A4 | PRENYLATION INHIBITORS CONTAINING DIMETHYL-CYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY INC (US) | 2006-11-08 | — | — | EP | claimed |
| EP-1534680-A4 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY INC (US) | 2006-06-07 | — | — | EP | claimed |
| EP-1534279-A2 | PRENYLATION INHIBITORS CONTAINING DIMETHYL-CYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY, INC. (US) | 2005-06-01 | — | — | EP | claimed |
| EP-1534680-A1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY, INC. (US) | 2005-06-01 | — | — | EP | claimed |
| US-20050004122-A1 | Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use | DEVELOPMENT PARTNERS, LLC | 2005-01-06 | — | — | US | claimed |
| US-20040116425-A1 | Prenylation inhibitors and methods of their synthesis and use | X-CHEM, INC. | 2004-06-17 | — | — | US | claimed |
| WO-2004016741-A2 | PRENYLATION INHIBITORS CONTAINING DIMETHYL-CYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY, INC. (US) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016592-A1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY, INC. (US) | 2004-02-26 | — | — | WO | claimed |
| JP-7025852-A | — | — | None | — | — | JP | disclosed |
| JP-59167571-A | — | — | None | — | — | JP | disclosed |
| US-4370477-A | ANTIULCER AGENT | JOHN WYETH AND BROTHER LIMITED (GB) | 1983-01-25 | — | — | US | disclosed |
| US-4304781-A | Treatment of ulcers and hypertension | JOHN WYETH & BROTHER LIMITED (GB) | 1981-12-08 | — | — | US | disclosed |
| US-4050921-A | Regulation of the natural growth or development of plants with 2-sulfinyl or 2-sulfonyl pyridine N-oxide compounds | UNIROYAL INC. (US) | 1977-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004122-A1 | Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use | RCE1, GGPS1, FNTA | POLB 2690/4885MAPT 3212/4885HSD17B10 1090/4885 |
| US-20070149549-A1 | 3-(Pyrid-3-yl)-5-(thiophen-2-yl)-pyrazoles; prenyl-protein transferase inhibitors | FNTA, PTAR1, ZMPSTE24 | POLB 4024/4885MAPT 1219/4885HSD17B10 1434/4885 |
| US-20070249010-A1 | Methods for treating glaucoma and macular degeneration | RHOA, RHOT2, ROCK1 | POLB 1782/4885MAPT 489/4885HSD17B10 1490/4885 |
| US-20080119524-A1 | PRENYLATION INHIBITORS CONTAINING DIMETHYLCYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | RCE1, GGPS1, FNTA | POLB 2690/4885MAPT 3212/4885HSD17B10 1090/4885 |
| US-20110009463-A1 | GERANYLGERANYL TRANSFERASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME | FNTA, GGPS1, PTAR1 | POLB 3766/4885MAPT 1870/4885HSD17B10 371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.