Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 5/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21605545 | 1.00 | MAPT (0.40) | MAPTLMNANPC1RAB9AHTT | |
| SCHEMBL3371450 | 0.86 | LCK (0.44) | MAPTNPC1RAB9AERN1MEN1 | |
| SCHEMBL17161028 | 0.84 | MAPT (0.42) | MAPTLMNANPC1RAB9AMEN1 | |
| SCHEMBL3371926 | 0.84 | MEN1 (0.39) | MAPTNPC1RAB9AERN1MEN1 | |
| Hydrochloric Acid SCHEMBL17161072 | 0.84 | LCK (0.43) | MAPTNPC1RAB9AERN1MEN1 | |
| SCHEMBL28602447 | 0.84 | GSK3B (0.45) | MAPTHTTBACE1SMN1; SMN2ALDH1A1 | |
| SCHEMBL25192702 | 0.82 | ALOX12 (0.35) | MAPTNPC1RAB9AERN1MEN1 | |
| SCHEMBL31164567 | 0.82 | ALOX12 (0.35) | MAPTNPC1RAB9AERN1MEN1 | |
| SCHEMBL18361981 | 0.81 | KMT2A (0.40) | MAPTLMNANPC1RAB9AHTT | |
| SCHEMBL31605278 | 0.81 | HPGDS (0.39) | MAPTNPC1RAB9AERN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114245794-B | Compounds for the treatment of huntington's disease | PTC医疗公司 | 2024-09-13 | — | — | CN | disclosed |
| CN-114245794-A | Compounds for the treatment of huntington's disease | PTC医疗公司 | 2022-03-25 | — | — | CN | disclosed |
| EP-3969446-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2022-03-23 | — | — | EP | disclosed |