Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25313050 | 1.00 | KDM4E (0.51) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL29466302 | 0.88 | KDM4E (0.52) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL25312201 | 0.88 | KDM4E (0.52) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL25878981 | 0.88 | KDM4E (0.54) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL25877628 | 0.85 | KDM4E (0.52) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL29484624 | 0.85 | RAB9A (0.56) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL25311588 | 0.85 | RAB9A (0.56) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL25311960 | 0.83 | KDM4E (0.56) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL25881212 | 0.81 | KDM4E (0.49) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL29466339 | 0.80 | KDM4E (0.51) | KDM4ESMN1; SMN2RAB9ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057932-A1 | CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | 上海医药集团股份有限公司 | 2022-03-24 | — | — | WO | disclosed |
| WO-2022057928-A1 | CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | 上海医药集团股份有限公司 | 2022-03-24 | — | — | WO | disclosed |
| CN-114195780-A | Carbonyl heterocyclic compound and application thereof | 上海医药集团股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-114195806-A | Carbonyl heterocyclic compound and application thereof | 上海医药集团股份有限公司 | 2022-03-18 | — | — | CN | disclosed |