Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946928 | 0.99 | TSHR (0.51) | TSHRCHRM5CHRM1CHRM3FABP3 | |
| Hydrochloric Acid SCHEMBL16667567 | 0.91 | THRB (0.45) | TSHRCHRM5CHRM1CHRM3FABP3 | |
| SCHEMBL16558586 | 0.91 | THRB (0.45) | TSHRCHRM5CHRM1CHRM3FABP3 | |
| SCHEMBL180655 | 0.91 | THRB (0.45) | TSHRCHRM5CHRM1CHRM3FABP3 | |
| SCHEMBL28595957 | 0.90 | TSHR (0.60) | TSHRFABP3APEX1POLBHTT | |
| SCHEMBL345781 | 0.89 | TSHR (0.59) | TSHRAPEX1POLBHTTTDP1 | |
| SCHEMBL28329138 | 0.89 | TSHR (0.51) | TSHRCHRM5CHRM1CHRM3FABP3 | |
| SCHEMBL346466 | 0.88 | TSHR (0.62) | TSHRAPEX1POLBHTTTDP1 | |
| SCHEMBL3447994 | 0.88 | TSHR (0.62) | TSHRAPEX1POLBHTTTDP1 | |
| SCHEMBL16142 | 0.88 | TSHR (0.62) | TSHRAPEX1POLBHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1433488-B1 | ARTIFICIAL JOINT MEMBER MADE OF POLYMERIC MATERIAL | KOBE STEEL LTD (JP) | 2010-11-03 | — | — | EP | disclosed |
| US-7785372-B2 | Artificial joint member with grafted polymer surface | KABUSHIKI KAISHA KOBE SEIKO SHO (JP) | 2010-08-31 | — | — | US | disclosed |
| US-20040243249-A1 | Artificial joint member made of polymeric material | TAKATORI, YOSHIO (6.25%) (JP) | 2004-12-02 | — | — | US | disclosed |
| EP-1433488-A1 | ARTIFICIAL JOINT MEMBER MADE OF POLYMERIC MATERIAL | KABUSHIKI KAISHA KOBE SEIKO SHO (JP) | 2004-06-30 | — | — | EP | disclosed |