Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22778153 | 1.00 | TNKS2 (0.43) | TNKS2ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL4303038 | 0.86 | ALDH1A1 (0.55) | ALDH1A1CYP3A4TSHRTDP1HSD17B1 | |
| SCHEMBL12440897 | 0.82 | ALDH1A1 (0.46) | ALDH1A1CYP3A4TSHRTDP1KDM4E | |
| SCHEMBL306113 | 0.81 | — | — | |
| SCHEMBL29421562 | 0.81 | — | — | |
| SCHEMBL16200431 | 0.80 | ALDH1A1 (0.48) | TNKS2ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL458236 | 0.80 | ALDH1A1 (0.48) | TNKS2ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL3138385 | 0.79 | ALDH1A1 (0.40) | ALDH1A1CYP3A4KDM4EACHEMAPT | |
| Fluoride SCHEMBL27656662 | 0.79 | ALDH1A1 (0.40) | ALDH1A1CYP3A4KDM4EACHEMAPT | |
| Ammonia Solution, Strong SCHEMBL28164484 | 0.79 | ALDH1A1 (0.40) | ALDH1A1CYP3A4KDM4EACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983392-A2 | COMPOUNDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | SRX Cardio, LLC (US) | 2022-04-20 | — | — | EP | disclosed |
| CN-114206843-A | Compounds for modulating proprotein convertase subtilisin/Kexin type 9(PCSK9) | SRX心脏有限责任公司 | 2022-03-18 | — | — | CN | disclosed |