Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24746007 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2ARMAOBMEN1MAPK1 | |
| SCHEMBL30065009 | 0.83 | MAOB (0.57) | SMN1; SMN2MAOBMAOACYP1A2CYP2C19 | |
| SCHEMBL8251097 | 0.83 | MAOB (0.57) | SMN1; SMN2MAOBMAOACYP1A2CYP2C19 | |
| SCHEMBL31632684 | 0.83 | MAOB (0.39) | MAOBMAOAGRIN2B | |
| SCHEMBL190181 | 0.82 | MAOB (0.55) | SMN1; SMN2MAOBMAOAPOLB | |
| SCHEMBL29468740 | 0.82 | HSD17B10 (0.49) | MEN1MAPK1KMT2AMAOAMAPT | |
| SCHEMBL16769862 | 0.78 | RXRA (0.39) | MAOBMAOAGRIN2B | |
| SCHEMBL29468842 | 0.78 | RXRA (0.44) | MAOBMAOAGRIN2B | |
| SCHEMBL12260777 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2ARMAOBMEN1MAPK1 | |
| SCHEMBL171645 | 0.77 | MRGPRX4 (0.53) | SMN1; SMN2ARMAOBMAOASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228761-A1 | 2-OXO-DIHYDROQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS GABA TYPE A RECEPTOR MODULATORS | University College Cardiff Consultants Limited (GB) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022079432-A1 | 2-OXO-DIHYDROQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS GABA TYPE A RECEPTOR MODULATORS | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2022-04-21 | — | — | WO | disclosed |