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SCHEMBL2946958

SCHEMBL2946958

CSCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)C(C)C

nearest known ligand 0.49

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ OPRM1 P35372 7/20 0.44
▸ OPRK1 P41145 7/20 0.44
▸ F2 P00734 1/20 0.44
▸ NTSR2 O95665 3/20 0.44
▸ NTSR1 P30989 3/20 0.44
▸ SORT1 Q99523 3/20 0.44
▸ APLNR P35414 1/20 0.44
▸ CXCR4 P61073 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2946942 1.00 OPRM1 (0.44) OPRM1OPRK1F2NTSR2NTSR1
SCHEMBL30487567 0.91 NTSR2 (0.47) OPRM1OPRK1F2NTSR2NTSR1
SCHEMBL30120960 0.88 OPRM1 (0.47) OPRM1OPRK1APLNR
SCHEMBL30173956 0.87 APLNR (0.43) OPRM1OPRK1APLNR
SCHEMBL30676238 0.86 EPHA2 (0.46) OPRM1OPRK1NTSR2NTSR1SORT1
SCHEMBL31099288 0.86 F2 (0.54) OPRM1OPRK1F2NTSR2NTSR1
SCHEMBL30392594 0.86 F2 (0.54) OPRM1OPRK1F2NTSR2NTSR1
SCHEMBL29607267 0.86 F2 (0.54) OPRM1OPRK1F2NTSR2NTSR1
SCHEMBL29887046 0.86 F2 (0.47) OPRM1OPRK1F2NTSR2NTSR1
SCHEMBL10595911 0.85 EPHA2 (0.55) OPRM1OPRK1APLNRCXCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7754858-B2 Antibodies to tumor necrosis factor receptor associated factor polypeptides GENENTECH, INC. (US) 2010-07-13 — — US disclosed
EP-2011873-A2 Tumor necrosis factor receptor-associated factors Genentech, Inc. (US) 2009-01-07 — — EP disclosed
EP-0760851-B1 TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED FACTORS GENENTECH INC (US) 2008-07-09 — — EP disclosed
US-20070243202-A1 TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED FACTORS GENENTECH, INC. (US) 2007-10-18 — — US disclosed
US-7244836-B2 Tumor necrosis factor receptor-associated factors GENENTECH, INC. (US) 2007-07-17 — — US disclosed
US-20030120043-A1 Tumor necrosis factor receptor-associated factors GENENTECH, INC. 2003-06-26 — — US disclosed
US-5869612-A AMINO ACID SEQUENCE OF ISOLATED PROTEIN INVOLVED IN POST-RECEPTOR SIGNAL TRANSDUCTION; TREATMENT OF RHEUMATOID ARTHRITIS AND SEPTIC SHOCK GENETECH, INC. (US) 1999-02-09 — — US disclosed
US-5741667-A NUCLEIC ACID WHICH CODES FOR A RECEPTOR PROTEIN BY ACTING AS A VECTOR FOR GENETICALLY ENGINEERED CELLS GENENTECH, INC. (US) 1998-04-21 — — US disclosed
US-5708142-A AMINO ACID SEQUENCE GENENTECH, INC. (US) 1998-01-13 — — US disclosed
US-5670319-A Assay for tumor necrosis factor receptor-associated factors GENENTECH, INC. (US) 1997-09-23 — — US disclosed