Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 11/20 | 0.32 |
| ▸ | FEN1 | P39748 | 11/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24333951 | 0.85 | ALOX5AP (0.37) | KMT2ANPC1RAB9AALOX5APFEN1 | |
| SCHEMBL29469812 | 0.85 | ALOX5AP (0.37) | KMT2ANPC1RAB9AALOX5APFEN1 | |
| SCHEMBL24334281 | 0.84 | ALOX5AP (0.32) | KMT2AALOX5APFEN1MAPTALDH1A1 | |
| SCHEMBL24334285 | 0.83 | NPC1 (0.33) | KMT2ANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL24333923 | 0.82 | HCRTR1 (0.37) | KMT2ANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL24334215 | 0.81 | KMT2A (0.37) | KMT2ANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL24333714 | 0.81 | ACLY (0.40) | KMT2ANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL29469673 | 0.80 | KMT2A (0.38) | KMT2ANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL29469648 | 0.80 | KMT2A (0.36) | KMT2ANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL24333403 | 0.79 | KMT2A (0.35) | KMT2ANPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |