Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GPR6 | P46095 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BCL9 | O00512 | 2/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24334016 | 1.00 | ALDH1A1 (0.36) | ALDH1A1GPR6SCN9ATRPV1GPR119 | |
| SCHEMBL24333795 | 0.98 | ALDH1A1 (0.36) | ALDH1A1GPR6SCN9ATRPV1GPR119 | |
| SCHEMBL29469633 | 0.98 | ALDH1A1 (0.36) | ALDH1A1GPR6SCN9ATRPV1GPR119 | |
| SCHEMBL29469691 | 0.90 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24333774 | 0.90 | ALDH1A1 (0.44) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL24333736 | 0.88 | SCN9A (0.38) | ALDH1A1SCN9ASCN1ASCN8A | |
| SCHEMBL29469681 | 0.88 | SCN9A (0.38) | ALDH1A1SCN9ASCN1ASCN8A | |
| SCHEMBL24333358 | 0.88 | SCN9A (0.36) | SCN9ALMNASMN1; SMN2 | |
| SCHEMBL24334459 | 0.88 | PTGDR (0.35) | ALDH1A1TRPV1LMNA | |
| SCHEMBL29469663 | 0.88 | PTGDR (0.35) | ALDH1A1TRPV1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |