Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.33 |
| ▸ | FABP4 | P15090 | 2/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SCN1A | P35498 | 3/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24333998 | 1.00 | ALDH1A1 (0.34) | ALDH1A1RECQLNPSR1SCN9AFABP4 | |
| SCHEMBL24333795 | 0.88 | ALDH1A1 (0.36) | ALDH1A1SCN9AFABP4FABP5RORC | |
| SCHEMBL29469633 | 0.88 | ALDH1A1 (0.36) | ALDH1A1SCN9AFABP4FABP5RORC | |
| SCHEMBL24333358 | 0.88 | SCN9A (0.36) | SCN9AFABP4FABP5MAPTTP53 | |
| SCHEMBL29469640 | 0.88 | ACACB (0.39) | ALDH1A1SCN9AACACBSLC6A9 | |
| SCHEMBL24333992 | 0.88 | ACACB (0.39) | ALDH1A1SCN9AACACBSLC6A9 | |
| SCHEMBL29469664 | 0.88 | ALDH1A1 (0.44) | ALDH1A1RECQLNPSR1ACACBMAPT | |
| SCHEMBL24333608 | 0.87 | SCN9A (0.35) | ALDH1A1SCN9AFABP4FABP5RORC | |
| SCHEMBL24314216 | 0.87 | SCN9A (0.35) | SCN9AFABP4FABP5 | |
| SCHEMBL29587379 | 0.87 | SCN9A (0.35) | SCN9AFABP4FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |