Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469796 | 1.00 | CA1 (0.47) | CA1CA2CA9KDM4EALDH1A1 | |
| SCHEMBL12180748 | 0.84 | CA1 (0.44) | CA1CA2CA9ADRA1DADRA1A | |
| SCHEMBL29469838 | 0.84 | CA1 (0.42) | CA1CA2CA9KDM4EALDH1A1 | |
| SCHEMBL29469899 | 0.81 | SMN1; SMN2 (0.41) | CA1CA2CA9ALDH1A1ADRA1D | |
| SCHEMBL31536845 | 0.80 | KMT2A (0.60) | CA1CA2CA9ALDH1A1KMT2A | |
| SCHEMBL5188196 | 0.80 | KMT2A (0.60) | CA1CA2CA9ALDH1A1KMT2A | |
| SCHEMBL22588315 | 0.80 | CA1 (0.53) | CA1CA2CA9ALDH1A1ADRA1D | |
| SCHEMBL27382367 | 0.79 | CA2 (0.50) | CA1CA2CA9KDM4EALDH1A1 | |
| SCHEMBL29469865 | 0.77 | PTGES2 (0.55) | CA1CA2CA9ALDH1A1ADRA1D | |
| SCHEMBL2247901 | 0.77 | PTGES2 (0.55) | CA1CA2CA9ALDH1A1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |