Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 5/20 | 0.33 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | CA9 | Q16790 | 5/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491302 | 0.83 | POLB (0.38) | CSNK1A1CSNK1DCSNK1ECSNK1G2CSNK1G1 | |
| SCHEMBL2871943 | 0.79 | CA12 (0.47) | ALDH1A1L3MBTL1TRPV4CA12CA1 | |
| SCHEMBL812489 | 0.77 | CYP1A2 (0.46) | SLC22A12ALDH1A1HIPK2TDP1KMT2A | |
| SCHEMBL17709907 | 0.76 | AXL (0.51) | CSNK1A1CSNK1DCSNK1ECSNK1G2CSNK1G1 | |
| SCHEMBL640546 | 0.76 | CYP1A2 (0.54) | SLC22A12ALDH1A1HTR6TRPV4TDP1 | |
| SCHEMBL27143147 | 0.76 | CA12 (0.38) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL1828055 | 0.76 | CA12 (0.42) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL289039 | 0.72 | GAA (0.43) | CSNK1A1CSNK1DCSNK1ECSNK1G2CSNK1G1 | |
| SCHEMBL16261223 | 0.71 | CSNK1A1 (0.43) | CSNK1A1CSNK1DCSNK1ECSNK1G2CSNK1G1 | |
| SCHEMBL115053 | 0.70 | CYP3A4 (0.56) | KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |