Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.56 |
| ▸ | PRKCG | P05129 | 6/20 | 0.56 |
| ▸ | PRKCB | P05771 | 6/20 | 0.56 |
| ▸ | PRKCA | P17252 | 6/20 | 0.56 |
| ▸ | PRKCH | P24723 | 6/20 | 0.56 |
| ▸ | PRKCI | P41743 | 6/20 | 0.56 |
| ▸ | PRKCE | Q02156 | 6/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.56 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.56 |
| ▸ | PRKD1 | Q15139 | 6/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | PRKACA | P17612 | 4/20 | 0.56 |
| ▸ | PRKACG | P22612 | 4/20 | 0.56 |
| ▸ | PRKACB | P22694 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29546384 | 1.00 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| Hydrochloric Acid SCHEMBL29469852 | 0.98 | LMNA (0.57) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| Hydrochloric Acid SCHEMBL987360 | 0.98 | LMNA (0.57) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL28592488 | 0.88 | PRKD3 (0.49) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL28586335 | 0.87 | PRKCZ (0.62) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3129943 | 0.86 | TNF (0.46) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL30002842 | 0.86 | TNF (0.46) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL6967362 | 0.85 | CYP3A4 (0.59) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL28591143 | 0.85 | PRKD3 (0.49) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL1551138 | 0.82 | CA1 (0.61) | CYP3A4PRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 379 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119081574-A | Flame-retardant PET (polyethylene terephthalate) adhesive tape and preparation method thereof | 常州市白鹭电器有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-118812509-A | Method for efficiently synthesizing fasudil hydrochloride | 山东新时代药业有限公司 | 2024-10-22 | — | — | CN | claimed |
| US-20240287027-A1 | PREPARATION METHOD FOR COMPOUND FASUDIL HYDROCHLORIDE | EAST CHINA UNIVERSITY OF SCIENCE & TECHNOLOGY (CN) | 2024-08-29 | — | — | US | claimed |
| WO-2024112610-A2 | PREPARATION METHOD OF FASUDIL HYDROCHLORIDE HEMIHYDRATE | WOOLSEY PHARMACEUTICALS, INC. (US) | 2024-05-30 | — | — | WO | claimed |
| CN-112010805-B | Refining method of fasudil hydrochloride | 山东威高药业股份有限公司 | 2023-12-05 | — | — | CN | claimed |
| WO-2022262548-A1 | PREPARATION METHOD FOR COMPOUND FASUDIL HYDROCHLORIDE | 华东理工大学 | 2022-12-22 | — | — | WO | claimed |
| CN-113372329-B | Preparation method of fasudil hydrochloride compound | 华东理工大学 | 2022-10-18 | — | — | CN | claimed |
| CN-108752274-B | Preparation method of 5-isoquinoline sulfonyl chloride | 遂成药业股份有限公司 | 2022-03-29 | — | — | CN | claimed |
| CN-111909088-B | Method for preparing isoquinoline hydrochloride intermediate and Rho kinase inhibitor by using BTC/Ph3PO chloro-system | 浙江工业大学 | 2022-03-01 | — | — | CN | claimed |
| CN-113372329-A | Preparation method of fasudil hydrochloride compound | 华东理工大学 | 2021-09-10 | — | — | CN | claimed |
| CN-112010805-A | Method for refining fasudil hydrochloride | 山东威高药业股份有限公司 | 2020-12-01 | — | — | CN | claimed |
| CN-111909088-A | Utilizing BTC/Ph3Method for preparing isoquinoline hydrochloride intermediate and Rho kinase inhibitor by PO chloro system | 浙江工业大学 | 2020-11-10 | — | — | CN | claimed |
| CN-111153856-A | Preparation method of fasudil hydrochloride impurity with genotoxicity | 湖南增达生物科技有限公司 | 2020-05-15 | — | — | CN | claimed |
| CN-109970712-A | A kind of refining methd of Fasudic hydrochloride | 徐州万邦金桥制药有限公司 | 2019-07-05 | — | — | CN | claimed |
| CN-108752274-A | A kind of preparation method of 5- isoquinoline sulfonyl chlorides | 遂成药业股份有限公司 | 2018-11-06 | — | — | CN | claimed |
| CN-103509002-B | Purification decolorization method of fasudil hydrochloride | XUZHOU WANBANG JINQIAO PHARMA CO LTD | 2015-05-13 | — | — | CN | claimed |
| CN-102993178-A | Isoquinoline compound with Rho kinase inhibition activity and preparation method and application thereof | TIANJIN CHASESUN PHARM CO LTD | 2013-03-27 | — | — | CN | claimed |
| EP-0061673-B1 | ISOQUINOLINESULFONYL DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-10-24 | — | — | EP | claimed |
| EP-0109023-A1 | Isoquinolinesulfonamide derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-05-23 | — | — | EP | claimed |
| EP-0061673-A1 | Isoquinolinesulfonyl derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-10-06 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287027-A1 | PREPARATION METHOD FOR COMPOUND FASUDIL HYDROCHLORIDE | BAD, CASP5, REN | CYP3A4 348/4885PRKD3 1290/4885PRKCG 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.