Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | UGCG | Q16739 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23069425 | 1.00 | USP30 (0.39) | USP30LRRK2EGLN1UGCGGPR6 | |
| SCHEMBL24370936 | 0.92 | GPR6 (0.41) | USP30EGLN1UGCGGPR6ACKR3 | |
| SCHEMBL23069494 | 0.90 | CTSL (0.44) | USP30LRRK2EGLN1UGCGGPR6 | |
| SCHEMBL23069404 | 0.89 | LRRK2 (0.36) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL29546047 | 0.89 | LRRK2 (0.36) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL30370549 | 0.89 | LCLAT1 (0.34) | USP30TLR9TLR8TLR7ACKR3 | |
| SCHEMBL30370285 | 0.89 | LCLAT1 (0.34) | USP30TLR9TLR8TLR7ACKR3 | |
| SCHEMBL24073663 | 0.89 | LCLAT1 (0.34) | USP30TLR9TLR8TLR7ACKR3 | |
| SCHEMBL24072856 | 0.89 | LCLAT1 (0.34) | USP30TLR9TLR8TLR7ACKR3 | |
| SCHEMBL24370923 | 0.88 | EGLN1 (0.35) | EGLN1UGCGGPR6ACKR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4025573-B9 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2024-11-20 | — | — | EP | claimed |
| EP-4025573-B1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2024-07-24 | — | — | EP | claimed |
| CN-114341133-B | Substituted cyanopyrrolidines having USP30 inhibitor activity | 特殊治疗有限公司 | 2024-02-27 | — | — | CN | claimed |
| EP-4025573-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2022-07-13 | — | — | EP | claimed |
| CN-114341133-A | Substituted cyanopyrrolidines with USP30 inhibitor activity | 特殊治疗有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-114341133-B | Substituted cyanopyrrolidines having USP30 inhibitor activity | 特殊治疗有限公司 | 2024-02-27 | — | — | CN | disclosed |
| EP-4025573-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2022-07-13 | — | — | EP | disclosed |
| CN-114341133-A | Substituted cyanopyrrolidines with USP30 inhibitor activity | 特殊治疗有限公司 | 2022-04-12 | — | — | CN | disclosed |