Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | UGCG | Q16739 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29546047 | 1.00 | LRRK2 (0.36) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL29158603 | 0.90 | CTSS (0.36) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL30798694 | 0.90 | CTSS (0.36) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL23085662 | 0.90 | CTSS (0.36) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL29158599 | 0.90 | CTSS (0.36) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL23069425 | 0.89 | USP30 (0.39) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL29470211 | 0.89 | USP30 (0.39) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL23069408 | 0.89 | LRRK2 (0.39) | LRRK2EGLN1UGCGGPR6TLR9 | |
| SCHEMBL25304785 | 0.87 | ADORA2A (0.36) | TLR9TLR8TLR7ACKR3KCNH2 | |
| SCHEMBL23069407 | 0.85 | USP30 (0.42) | LRRK2EGLN1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4025573-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2022-07-13 | — | — | EP | disclosed |
| CN-114341133-A | Substituted cyanopyrrolidines with USP30 inhibitor activity | 特殊治疗有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021043870-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2021-03-11 | — | — | WO | disclosed |