Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29471163 | 0.83 | HDAC1 (0.44) | GAAHDAC1HDAC6SIGMAR1SMN1; SMN2 | |
| SCHEMBL3809440 | 0.78 | HDAC1 (0.40) | GAAHDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL29471188 | 0.75 | POLB (0.41) | GAAHDAC1HDAC6 | |
| SCHEMBL18386281 | 0.73 | RARB (0.45) | HDAC1HDAC6ALDH1A1KDM4E | |
| SCHEMBL3808760 | 0.73 | SIGMAR1 (0.39) | HDAC1HDAC6SIGMAR1MAPTLMNA | |
| SCHEMBL28825820 | 0.73 | SLC22A12 (0.46) | GAAHDAC1HDAC6ALDH1A1MAPT | |
| SCHEMBL23794645 | 0.69 | GAA (0.55) | GAASIGMAR1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18821250 | 0.69 | GAA (0.55) | GAASIGMAR1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18819768 | 0.69 | GAA (0.55) | GAASIGMAR1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL12715142 | 0.69 | HDAC1 (0.42) | GAAHDAC1HDAC6SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4210683-A1 | HETEROCYCLIC COMPOUNDS AS CBP/EP300 BROMODOMAIN INHIBITORS | Aurigene Oncology Limited (IN) | 2023-07-19 | — | — | EP | disclosed |
| CN-116368128-A | Heterocyclic compounds as CBP/EP300 bromodomain inhibitors | 奥瑞基尼肿瘤有限公司 | 2023-06-30 | — | — | CN | disclosed |
| WO-2022053967-A1 | HETEROCYCLIC COMPOUNDS AS CBP/EP300 BROMODOMAIN INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-03-17 | — | — | WO | disclosed |