⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10703485 | 0.82 | — | — | |
| SCHEMBL9843077 | 0.70 | — | — | |
| SCHEMBL385951 | 0.70 | — | — | |
| SCHEMBL5357002 | 0.69 | — | — | |
| SCHEMBL2482994 | 0.66 | — | — | |
| SCHEMBL20047789 | 0.65 | — | — | |
| SCHEMBL5828709 | 0.63 | LMNA (0.32) | — | |
| SCHEMBL8586814 | 0.62 | — | — | |
| SCHEMBL314815 | 0.60 | — | — | |
| SCHEMBL25146 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034510-A1 | OLIGONUCLEOTIDES COMPRISING A C5-MODIFIED PYRIMIDINE | Alnylam Pharmaceuticals Inc. (US) | 2016-06-22 | — | — | EP | disclosed |
| US-7674778-B2 | Oligonucleotides comprising a conjugate group linked through a C5-modified pyrimidine | ALNYLAM PHARMACEUTICALS (US) | 2010-03-09 | — | — | US | disclosed |
| EP-1750776-A2 | OLIGONUCLEOTIDES COMPRISING A C5-MODIFIED PYRIMIDINE | Alnylam Pharmaceuticals Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2006073458-A2 | OLIGONUCLEOTIDES COMPRISING A C5-MODIFIED PYRIMIDINE | ALNYLAM PHARMACEUTICALS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |
| US-20050288244-A1 | Oligonucleotides comprising a C5-modified pyrimidine | ALNYLAM PHARMACEUTICALS, INC. (US) | 2005-12-29 | — | — | US | disclosed |