Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.40 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.40 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29379034 | 0.86 | MAPT (0.47) | LMNAMAPK8MAPK10ALDH1A1MEN1 | |
| SCHEMBL29471927 | 0.85 | MAPK8 (0.56) | LMNAKMOMAPK8MAPK10DHFR | |
| SCHEMBL27329825 | 0.78 | LMNA (0.71) | LMNAKMODHFRAGXTALDH1A1 | |
| SCHEMBL14961830 | 0.75 | HTT (0.56) | LMNAKMODHFRAGXTALDH1A1 | |
| SCHEMBL22466259 | 0.72 | LMNA (0.46) | LMNAKMODHFRAGXTALDH1A1 | |
| SCHEMBL31588063 | 0.72 | NOTUM (0.45) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL29378783 | 0.72 | HSD17B1 (0.45) | LMNAALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL29379236 | 0.70 | NOTUM (0.47) | ALDH1A1MAPTHTTNOTUMKEAP1 | |
| SCHEMBL14961831 | 0.69 | LMNA (0.53) | LMNAKMODHFRAGXTALDH1A1 | |
| SCHEMBL18726009 | 0.69 | NOTUM (0.55) | MAPK8MAPK10NOTUMKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220041578-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2022-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220041578-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | CRBN, CUL4B, UBQLN1 | LMNA 2811/4885KMO 1484/4885MAPK8 4253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.