Nitrofurantoin

Nitrofurantoin

SCHEMBL29472

O=C1CN(N=Cc2ccc([N+](=O)[O-])o2)C(=O)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 7/20 1.00
▸ MAPT P10636 6/20 1.00
▸ TDP1 Q9NUW8 5/20 1.00
▸ TP53 P04637 5/20 1.00
▸ MDM2 Q00987 4/20 1.00
▸ CYP1A2 P05177 3/20 1.00
▸ SMN1; SMN2 Q16637 3/20 1.00
▸ CYP3A4 P08684 2/20 1.00
▸ CISD1 Q9NZ45 2/20 1.00
▸ KDM4E B2RXH2 2/20 1.00
▸ ABCC4 O15439 1/20 1.00
▸ TSHR P16473 1/20 1.00
▸ MAOA P21397 1/20 1.00
▸ CASP7 P55210 1/20 1.00
▸ HSD17B10 Q99714 1/20 1.00
▸ KMT2A Q03164 3/20 0.67
▸ MEN1 O00255 2/20 0.67
▸ ABCB11 O95342 1/20 0.67
▸ ADORA1 P30542 1/20 0.67
▸ ALDH1A1 P00352 6/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nitrofurantoin SCHEMBL29471 1.00 LMNA (1.00) LMNAMAPTTDP1TP53MDM2
Nitrofurantoin SCHEMBL2508426 1.00 LMNA (1.00) LMNAMAPTTDP1TP53MDM2
Nitrofurantoin SCHEMBL29470 1.00 LMNA (1.00) LMNAMAPTTDP1TP53MDM2
Nitrofurantoin SCHEMBL668258 0.99 LMNA (0.97) LMNAMAPTTDP1TP53MDM2
Nitrofurantoin SCHEMBL547326 0.99 LMNA (0.97) LMNAMAPTTDP1TP53MDM2
Nitrofurantoin SCHEMBL3339581 0.99 LMNA (0.97) LMNAMAPTTDP1TP53MDM2
Nitrofurantoin SCHEMBL9813751 0.99 LMNA (0.97) LMNAMAPTTDP1TP53MDM2
Nitrofurantoin SCHEMBL3339573 0.99 LMNA (0.97) LMNAMAPTTDP1TP53MDM2
Nitrofurantoin SCHEMBL2323795 0.90 LMNA (0.81) LMNAMAPTTDP1TP53MDM2
Nitrofurantoin SCHEMBL2323793 0.90 LMNA (0.81) LMNAMAPTTDP1TP53MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 25876 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107208-A1 COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS THE METHODIST HOSPITAL (US) 2026-05-21 — — WO claimed
EP-4743122-A1 THERAPEUTIC SEALANTS BASED UPON DRUG CONJUGATES The Johns Hopkins University (US) 2026-05-20 — — EP claimed
EP-4743153-A1 MEDICAL SYSTEMS FOR TREATING CONDITIONS AND DISEASES OF THE PATIENT'S BODY CAVITIES UTT Urine Topical Treatment Ltd (IL) 2026-05-20 — — EP claimed
EP-4225277-B1 MESOPOROUS NANOPARTICLE SYSTEM TO INCREASE THE BIOFILM ERADICATION ACTIVITY BY MEANS OF THE CARRYING AND THE ADMINISTRATION OF AT LEAST ONE ACTIVE INGREDIENT AND RELATED PRODUCTION METHOD BRENTA S R L (IT) 2026-05-13 — — EP claimed
EP-4739326-A2 PRODUCTION & SECRETION OF AUXIN-LIKE MOLECULES IN BACTERIA SNIPR Biome ApS (DK) 2026-05-13 — — EP claimed
EP-4736841-A1 A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT IQ medical GmbH (DE) 2026-05-06 — — EP claimed
US-20260115234-A1 PRODUCTION & SECRETION OF AUXIN-LIKE MOLECULES IN BACTERIA SNIPR BIOME APS (DK) 2026-04-30 — — US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 — — US claimed
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 — — EP claimed
US-20260091119-A1 ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF GLIOMA CELLIS AG (CH) 2026-04-02 — — US claimed
EP-0126684-A2 Drug delivery system utilizing thermosetting gels MERCK & CO. INC. (US) 1984-11-28 — — EP claimed
EP-0078079-A2 Nitrofurantoin dosage form Norwich Eaton Pharmaceuticals, Inc. (US) 1983-05-04 — — EP claimed
US-4370313-A COATED WITH ACRYLIC RESIN EATON LABORATORIES, INC. (US) 1983-01-25 — — US claimed
EP-0069385-A2 Use of eucalyptol for enhancing skin permeation of bioaffecting agents MERCK & CO. INC. (US) 1983-01-12 — — EP claimed
EP-0036138-A2 Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide MERCK & CO. INC. (US) 1981-09-23 — — EP claimed
US-4288543-A SAMPLING IN LIQUID PHASE WITH ANTIGROWTH AGENTS-BIOLOGICAL PFIZER INC. (US) 1981-09-08 — — US claimed
US-4191772-A Instillation composition BOEHRINGER MANNHEIM GMBH (DE) 1980-03-04 — — US claimed
US-4152444-A RIFAMPICIN AND NITROFURANTOIN CIBA-GEIGY CORPORATION (US) 1979-05-01 — — US claimed
US-4122157-A TREATMENT OF URINARY TRACT INFECTIONS RICHARDSON-MERRELL INC. (US) 1978-10-24 — — US claimed
US-4053593-A PREVENTING AND CURING DISEASES IN FISH FRUMOFF LEW 1977-10-11 — — US claimed
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