Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Nitrofurantoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 7/20 | 0.97 |
| ▸ | MAPT | P10636 | 7/20 | 0.97 |
| ▸ | TP53 | P04637 | 5/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.97 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.97 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | MAOA | P21397 | 1/20 | 0.97 |
| ▸ | CASP7 | P55210 | 1/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrofurantoin SCHEMBL29472 | 0.99 | LMNA (1.00) | LMNAMAPTTP53TDP1SMN1; SMN2 | |
| Nitrofurantoin SCHEMBL29470 | 0.99 | LMNA (1.00) | LMNAMAPTTP53TDP1SMN1; SMN2 | |
| Nitrofurantoin SCHEMBL2508426 | 0.99 | LMNA (1.00) | LMNAMAPTTP53TDP1SMN1; SMN2 | |
| Nitrofurantoin SCHEMBL29471 | 0.99 | LMNA (1.00) | LMNAMAPTTP53TDP1SMN1; SMN2 | |
| Nitrofurantoin SCHEMBL668258 | 0.97 | LMNA (0.97) | LMNAMAPTTP53TDP1SMN1; SMN2 | |
| Nitrofurantoin SCHEMBL547326 | 0.97 | LMNA (0.97) | LMNAMAPTTP53TDP1SMN1; SMN2 | |
| Nitrofurantoin SCHEMBL3339581 | 0.97 | LMNA (0.97) | LMNAMAPTTP53TDP1SMN1; SMN2 | |
| Nitrofurantoin SCHEMBL3339573 | 0.97 | LMNA (0.97) | LMNAMAPTTP53TDP1SMN1; SMN2 | |
| Nitrofurantoin SCHEMBL2323793 | 0.89 | LMNA (0.81) | LMNAMAPTTP53TDP1SMN1; SMN2 | |
| Nitrofurantoin SCHEMBL2323795 | 0.89 | LMNA (0.81) | LMNAMAPTTP53TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021156838-A1 | TIO2 NANO-PARTICLES IMPREGNATED SURGICAL SILK SUTURE | CHANDRASHEKAR VIDYA KODIGE (IN) | 2021-08-12 | — | — | WO | claimed |
| US-4024871-A | POLYURETHANE | ETHICON, INC. (US) | 1977-05-24 | — | — | US | claimed |
| WO-2021156838-A1 | TIO2 NANO-PARTICLES IMPREGNATED SURGICAL SILK SUTURE | CHANDRASHEKAR VIDYA KODIGE (IN) | 2021-08-12 | — | — | WO | disclosed |
| US-20150173738-A1 | SURGICAL FIXATION DEVICE WITH ANTIBACTERIAL SUBSTANCE | ARTHREX, INC. | 2015-06-25 | — | — | US | disclosed |
| EP-0250038-B1 | SUSTAINED RELEASE CAPSULE | Norwich Eaton Pharmaceuticals, Inc. (US) | 1991-08-21 | — | — | EP | disclosed |
| EP-0250023-B1 | NITROFURANTOIN DOSAGE FORM | Norwich Eaton Pharmaceuticals, Inc. (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4798725-A | POLYVINYLPYRROLIDONE, CARBOXYVINYL POLYMER | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-01-17 | — | — | US | disclosed |
| US-4772473-A | RAPID-AND SUSTAINED-RELEASE CAPSULE | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0250038-A2 | Sustained release capsule | Norwich Eaton Pharmaceuticals, Inc. (US) | 1987-12-23 | — | — | EP | disclosed |
| EP-0250023-A1 | Nitrofurantoin dosage form | Norwich Eaton Pharmaceuticals, Inc. (US) | 1987-12-23 | — | — | EP | disclosed |
| US-4122158-A | FOR TREATMENT OF BURNS; BIODEGRADABLE HYDROPHOBIC POLYMER; SUSTAINED RELEASE | ALZA CORPORATION (US) | 1978-10-24 | — | — | US | disclosed |
| US-4024871-A | POLYURETHANE | ETHICON, INC. (US) | 1977-05-24 | — | — | US | disclosed |
| US-3987797-A | ANTIMICROBIAL SUTURES | ETHICON, INC. (US) | 1976-10-26 | — | — | US | disclosed |
| US-3983209-A | HYDROPHOBIC BIOERODIBLE POLYMER, MICROBIOCIDE OR PROTEOLYTIC ENZYME | ALZA CORPORATION (US) | 1976-09-28 | — | — | US | disclosed |