Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9626462 | 1.00 | LMNA (0.35) | LMNASMN1; SMN2CA12CA2CA9 | |
| SCHEMBL9625868 | 0.78 | LMNA (0.38) | LMNASMN1; SMN2CA12CA2CA9 | |
| SCHEMBL7754111 | 0.78 | LMNA (0.38) | LMNASMN1; SMN2CA12CA2CA9 | |
| SCHEMBL10123082 | 0.78 | LMNA (0.40) | LMNASMN1; SMN2CA12CA2CA9 | |
| SCHEMBL9627425 | 0.77 | LMNA (0.36) | LMNASMN1; SMN2CA12CA2CA9 | |
| SCHEMBL12036842 | 0.75 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2CA12CA2CA9 | |
| SCHEMBL13754207 | 0.75 | LMNA (0.41) | LMNASMN1; SMN2CA12CA2CA9 | |
| SCHEMBL25859859 | 0.75 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL10951849 | 0.73 | LMNA (0.34) | LMNASMN1; SMN2CA12CA2CA9 | |
| SCHEMBL9626063 | 0.73 | LMNA (0.34) | LMNASMN1; SMN2CA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908957-A | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114222737-B | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |