Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.49 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29473230 | 1.00 | LRRK2 (0.54) | LRRK2NPC1RAB9ALMNAUSP2 | |
| SCHEMBL29473245 | 0.84 | NPC1 (0.56) | NPC1RAB9ALMNAHTTL3MBTL1 | |
| SCHEMBL8247251 | 0.83 | NPC1 (0.55) | NPC1RAB9ALMNAHTTL3MBTL1 | |
| SCHEMBL29473195 | 0.82 | NPC1 (0.51) | NPC1RAB9AL3MBTL1AAK1BRD4 | |
| SCHEMBL5783658 | 0.81 | HTT (0.59) | NPC1RAB9ALMNAHTTL3MBTL1 | |
| SCHEMBL6584410 | 0.80 | LMNA (0.48) | LRRK2LMNAUSP2HTTL3MBTL1 | |
| SCHEMBL6584406 | 0.80 | LMNA (0.48) | LRRK2LMNAUSP2HTTL3MBTL1 | |
| SCHEMBL14648942 | 0.80 | NPC1 (0.70) | NPC1RAB9ALMNAHTTL3MBTL1 | |
| SCHEMBL16609975 | 0.79 | HTT (0.54) | NPC1RAB9ALMNAHTTL3MBTL1 | |
| SCHEMBL14648946 | 0.79 | HTT (0.57) | NPC1RAB9ALMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229062-A1 | BICYCLIC COMPOUNDS | Aligos Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081758-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |