Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247251 | 0.85 | NPC1 (0.55) | NPC1RAB9AHTTL3MBTL1LMNA | |
| SCHEMBL29473232 | 0.84 | LRRK2 (0.54) | NPC1RAB9AHTTL3MBTL1LMNA | |
| SCHEMBL29473230 | 0.84 | LRRK2 (0.54) | NPC1RAB9AHTTL3MBTL1LMNA | |
| SCHEMBL16193637 | 0.83 | ALOX15 (0.61) | NPC1RAB9AL3MBTL1LMNAMGLL | |
| SCHEMBL14648942 | 0.82 | NPC1 (0.70) | NPC1RAB9AHTTL3MBTL1LMNA | |
| SCHEMBL16193532 | 0.82 | NPC1 (0.69) | NPC1RAB9AHTTLMNAMGLL | |
| SCHEMBL30522295 | 0.82 | NPC1 (0.69) | NPC1RAB9AHTTLMNAMGLL | |
| SCHEMBL16609975 | 0.81 | HTT (0.54) | NPC1RAB9AHTTL3MBTL1LMNA | |
| SCHEMBL15330140 | 0.81 | NPC1 (0.53) | NPC1RAB9AHTTMGLLMAOB | |
| SCHEMBL14648946 | 0.81 | HTT (0.57) | NPC1RAB9AHTTL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229062-A1 | BICYCLIC COMPOUNDS | Aligos Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081758-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |