Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | EZH2 | Q15910 | 14/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28594996 | 1.00 | KDM4E (0.45) | KDM4EEZH2HDAC1HDAC6NPC1 | |
| SCHEMBL29473819 | 0.89 | EZH2 (0.43) | EZH2EZH1 | |
| SCHEMBL28598218 | 0.89 | EZH2 (0.43) | EZH2EZH1 | |
| SCHEMBL29473796 | 0.89 | EZH2 (0.42) | EZH2EZH1 | |
| SCHEMBL29473804 | 0.89 | L3MBTL1 (0.48) | EZH2NPC1MAPTEZH1 | |
| SCHEMBL28600925 | 0.89 | L3MBTL1 (0.48) | EZH2NPC1MAPTEZH1 | |
| SCHEMBL28609618 | 0.89 | EZH2 (0.42) | EZH2EZH1 | |
| SCHEMBL28597525 | 0.88 | EZH2 (0.42) | EZH2EZH1 | |
| SCHEMBL29473807 | 0.88 | EZH2 (0.42) | EZH2EZH1 | |
| SCHEMBL29473821 | 0.87 | EZH2 (0.43) | KDM4EEZH2EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113045494-B | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2022-04-26 | — | — | CN | disclosed |