Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 10/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16158618 | 0.86 | TSHR (0.33) | CA1CA2NOD1SLC6A5 | |
| SCHEMBL24486723 | 0.82 | CA1 (0.47) | CA1CA2NOD1SLC6A5TLR2 | |
| SCHEMBL20082765 | 0.81 | NOD1 (0.54) | CA1CA2NOD1SLC6A5TLR2 | |
| SCHEMBL30503485 | 0.78 | C3AR1 (0.41) | — | |
| SCHEMBL30068459 | 0.78 | NOD1 (0.64) | NOD1SLC6A5TLR2 | |
| SCHEMBL26353953 | 0.78 | NOD1 (0.51) | CA1CA2NOD1SLC6A5TLR2 | |
| SCHEMBL3933327 | 0.77 | SIRT6 (0.50) | CA1CA2TLR2 | |
| SCHEMBL8261479 | 0.77 | SIRT6 (0.50) | CA1CA2TLR2 | |
| SCHEMBL10533228 | 0.77 | NOD1 (0.46) | CA1CA2NOD1SLC6A5TLR2 | |
| SCHEMBL24295468 | 0.77 | NOD1 (0.50) | CA1CA2NOD1SLC6A5TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116457023-A | antibody-TLR agonist conjugates, methods and uses thereof | AMBRX公司 | 2023-07-18 | — | — | CN | disclosed |
| EP-4199968-A1 | ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF | Ambrx, Inc. (US) | 2023-06-28 | — | — | EP | disclosed |
| WO-2022040596-A1 | ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF | AMBRX, INC. (US) | 2022-02-24 | — | — | WO | disclosed |