Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539775 | 1.00 | SLC6A4 (0.52) | SLC6A4SLC6A3CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL25485749 | 0.87 | SLC6A4 (0.52) | SLC6A4SLC6A3CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL25327219 | 0.86 | KDM4E (0.49) | SLC6A4SLC6A3CYP2C19KDM4ELMNA | |
| SCHEMBL23539577 | 0.86 | ALPL (0.43) | SLC6A4SLC6A3CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29654773 | 0.84 | ABL1 (0.44) | SLC6A4SLC6A3KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL25486721 | 0.84 | ABL1 (0.44) | SLC6A4SLC6A3KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL29476278 | 0.84 | SLC6A4 (0.49) | SLC6A4SLC6A3CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL23541000 | 0.84 | SLC6A4 (0.49) | SLC6A4SLC6A3CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL24525459 | 0.83 | JAK2 (0.43) | SLC6A4SLC6A3CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL23540082 | 0.80 | SLC6A4 (0.56) | SLC6A4SLC6A3CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217071-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022066805-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-03-31 | — | — | WO | disclosed |