Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 6/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23540452 | 1.00 | CFTR (0.51) | CFTRABL1KDM4EGAAALDH1A1 | |
| SCHEMBL23539774 | 0.88 | GAA (0.48) | CFTRABL1KDM4EGAAALDH1A1 | |
| SCHEMBL29476391 | 0.88 | GAA (0.48) | CFTRABL1KDM4EGAAALDH1A1 | |
| SCHEMBL23557174 | 0.86 | ABL1 (0.44) | CFTRABL1KDM4EGAAALDH1A1 | |
| SCHEMBL29654654 | 0.84 | CFTR (0.50) | CFTRABL1KDM4EGAAALDH1A1 | |
| SCHEMBL24525035 | 0.84 | CFTR (0.50) | CFTRABL1KDM4EGAAALDH1A1 | |
| SCHEMBL29476232 | 0.82 | CFTR (0.52) | CFTRABL1KDM4EGAAALDH1A1 | |
| SCHEMBL23540410 | 0.82 | CFTR (0.52) | CFTRABL1KDM4EGAAALDH1A1 | |
| SCHEMBL23540576 | 0.81 | ALDH1A1 (0.41) | CFTRKDM4EGAAALDH1A1HSD17B10 | |
| SCHEMBL29476351 | 0.81 | ALDH1A1 (0.41) | CFTRKDM4EGAAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217071-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022133345-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022066805-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-03-31 | — | — | WO | disclosed |