Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23540410 | 1.00 | CFTR (0.52) | CFTRMAPTABL1KDM4EGAA | |
| SCHEMBL23539774 | 0.86 | GAA (0.48) | CFTRMAPTABL1KDM4EGAA | |
| SCHEMBL29476391 | 0.86 | GAA (0.48) | CFTRMAPTABL1KDM4EGAA | |
| SCHEMBL25328269 | 0.85 | CFTR (0.45) | CFTRKDM4EGAAALDH1A1HPGD | |
| SCHEMBL23557174 | 0.84 | ABL1 (0.44) | CFTRMAPTABL1KDM4EGAA | |
| SCHEMBL29654580 | 0.83 | CFTR (0.55) | CFTRMAPTABL1KDM4EGAA | |
| SCHEMBL24525042 | 0.83 | CFTR (0.55) | CFTRMAPTABL1KDM4EGAA | |
| SCHEMBL29476340 | 0.82 | CFTR (0.51) | CFTRMAPTABL1KDM4EGAA | |
| SCHEMBL23540452 | 0.82 | CFTR (0.51) | CFTRMAPTABL1KDM4EGAA | |
| SCHEMBL23539849 | 0.82 | ALDH1A1 (0.40) | CFTRMAPTKDM4EALDH1A1ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217071-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022066805-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-03-31 | — | — | WO | disclosed |