Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | LSS | P48449 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4515670 | 0.86 | KDM4E (0.76) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL18754030 | 0.83 | LSS (0.67) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL12082893 | 0.83 | KDM4E (0.85) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL95294 | 0.83 | LSS (0.67) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL27759916 | 0.79 | KDM4E (0.62) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL28292812 | 0.78 | SMN1; SMN2 (0.67) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL1921224 | 0.78 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL28374054 | 0.77 | KDM4E (0.55) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL10856726 | 0.77 | KDM4E (0.65) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL8144850 | 0.76 | HRH3 (0.71) | CYP3A4CYP2D6CYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | claimed |
| EP-1761520-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-03-14 | — | — | EP | claimed |
| WO-2006009741-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-01-26 | — | — | WO | claimed |
| EP-2231617-A1 | BENZIMIDAZOLE COMPOUNDS | Wyeth LLC (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009086138-A1 | BENZIMIDAZOLE COMPOUNDS | WYETH (US) | 2009-07-09 | — | — | WO | disclosed |