Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124360 | 0.84 | MEN1 (0.69) | ALDH1A1HSD17B10POLBTSHRMEN1 | |
| SCHEMBL7956657 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2AKR1C3CYP3A4ALDH1A1GAA | |
| SCHEMBL12082812 | 0.82 | LMNA (0.69) | SMN1; SMN2AKR1C3CYP3A4ALDH1A1GAA | |
| SCHEMBL6791126 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2AKR1C3CYP3A4ALDH1A1GAA | |
| SCHEMBL95296 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2AKR1C3CYP3A4ALDH1A1GAA | |
| SCHEMBL1921224 | 0.82 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1POLBTSHRMEN1 | |
| SCHEMBL5546278 | 0.81 | POLB (0.69) | ALDH1A1HSD17B10POLBTSHRMEN1 | |
| SCHEMBL23008892 | 0.81 | SMN1; SMN2 (0.75) | SMN1; SMN2AKR1C3CYP3A4ALDH1A1GAA | |
| SCHEMBL7954884 | 0.81 | SLC6A7 (0.63) | SMN1; SMN2AKR1C3CYP3A4ALDH1A1GAA | |
| SCHEMBL5908986 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2AKR1C3CYP3A4ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104350055-B | Bicyclic heteroaryl derivatives and application thereof as MNK1 and MNK2 regulator | 新加坡科技研究局 | 2019-05-31 | — | — | CN | disclosed |