Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24373031 | 1.00 | MAPK1 (0.34) | MAPK1CES1 | |
| SCHEMBL29478872 | 0.76 | CES1 (0.33) | CES1 | |
| SCHEMBL24373030 | 0.76 | CES1 (0.33) | CES1 | |
| SCHEMBL24373453 | 0.74 | ALDH1A1 (0.34) | MAPK1 | |
| SCHEMBL29479151 | 0.74 | ALDH1A1 (0.34) | MAPK1 | |
| SCHEMBL25608607 | 0.70 | MAPK1 (0.37) | MAPK1CES1 | |
| SCHEMBL24373461 | 0.66 | — | — | |
| SCHEMBL29478826 | 0.66 | — | — | |
| SCHEMBL30421685 | 0.64 | CES1 (0.41) | CES1 | |
| SCHEMBL31619448 | 0.63 | MEN1 (0.39) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232444-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022083569-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-04-28 | — | — | WO | disclosed |