Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24373030 | 1.00 | CES1 (0.33) | CES1LIMK1MEN1TSHRKMT2A | |
| SCHEMBL24373031 | 0.76 | MAPK1 (0.34) | CES1 | |
| SCHEMBL29478793 | 0.76 | MAPK1 (0.34) | CES1 | |
| SCHEMBL6770814 | 0.71 | MEN1 (0.39) | MEN1TSHRKMT2A | |
| SCHEMBL30572444 | 0.71 | MEN1 (0.39) | MEN1TSHRKMT2A | |
| SCHEMBL30421685 | 0.67 | CES1 (0.41) | CES1 | |
| SCHEMBL20398744 | 0.65 | CES1 (0.42) | CES1 | |
| SCHEMBL15829226 | 0.63 | CD44 (0.44) | CES1LIMK1MEN1TSHRKMT2A | |
| SCHEMBL24373489 | 0.62 | MEN1 (0.32) | MEN1TSHRKMT2A | |
| SCHEMBL29479092 | 0.62 | MEN1 (0.32) | MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232444-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022083569-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-04-28 | — | — | WO | disclosed |