Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24373489 | 1.00 | MEN1 (0.32) | MEN1TSHRKMT2AGAAMAPT | |
| SCHEMBL21962186 | 0.83 | GAA (0.34) | MEN1TSHRKMT2AGAAMAPT | |
| SCHEMBL27096420 | 0.79 | — | — | |
| SCHEMBL29479180 | 0.79 | — | — | |
| SCHEMBL26116307 | 0.77 | — | — | |
| SCHEMBL29478826 | 0.75 | — | — | |
| SCHEMBL24373461 | 0.75 | — | — | |
| SCHEMBL6770814 | 0.73 | MEN1 (0.39) | MEN1TSHRKMT2AGAAMAPT | |
| SCHEMBL30572444 | 0.73 | MEN1 (0.39) | MEN1TSHRKMT2AGAAMAPT | |
| SCHEMBL25296297 | 0.72 | WNT3A (0.32) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232444-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022083569-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-04-28 | — | — | WO | disclosed |